Pantothenic acid, also known as vitamin B5, is one of the water-soluble B vitamins and is sensitive to heat. The human body cannot produce this vitamin and must obtain it from food. Because pantothenic acid is present in almost all foods, its name derives from the Greek word "pantothen", meaning "everywhere". Particularly high amounts are found in yeast, liver, fish, egg yolk, grains and legumes.
Because the vitamin can only be stored in the body to a limited extent – mainly in the liver, kidneys and muscles – a regular intake is necessary. With a balanced diet, deficiency generally does not occur.
Pantothenic acid is an essential vitamin that plays a central role in many metabolic processes. One of its main tasks is to provide energy to the body, as it is a component of coenzyme A and is involved in the utilisation of carbohydrates, fats and proteins. This enables efficient conversion of food into energy required for physical and mental performance.
In addition, pantothenic acid is indispensable for the production of important substances. It is involved in the formation of steroid hormones, including sex hormones and cortisol, as well as in the body’s own synthesis of cholesterol and vitamin D. It is also required for the production of neurotransmitters, particularly acetylcholine, making it an important factor for nervous system function and mental performance.
Another important aspect is its role in the synthesis of fatty acids and proteins. Pantothenic acid supports the building of amino acids and the incorporation of fats into cell membranes. It also contributes to the normal function of energy metabolism and can help reduce fatigue.
Beyond these basic tasks, there is evidence that pantothenic acid may also be important for skin health. It influences the barrier function of the epidermis and may aid wound healing. Some studies suggest that high doses of pantothenic acid can reduce the number of skin blemishes in acne, although the scientific evidence is limited.
The vitamin also appears to be relevant during stress, as requirements may increase in such situations. Pantothenic acid is sometimes used for joint health, particularly in osteoarthritis and arthritis, although further studies are needed to confirm this effect.
Finally, it is suspected that certain gut bacteria may contribute to endogenous pantothenic acid production. Whether and to what extent the body can actually utilise this locally synthesised form is not yet fully established.
A deficiency of pantothenic acid often manifests through various non-specific symptoms. The most common complaints include persistent tiredness and exhaustion that do not disappear despite adequate sleep. Headaches, muscle weakness and muscle cramps may also occur and affect general well-being. Nausea, loss of appetite and sleep disorders may also be present, often accompanied by a lack of drive.
Another common symptom is "burning-feet syndrome", in which burning or tingling sensations occur in the feet. In severe cases, neurological symptoms such as numbness in the extremities can also develop. Other symptoms of vitamin B5 deficiency include mood swings, irritability and cognitive impairments such as memory problems and confusion.
Anyone who notices these symptoms for an extended period should consult a doctor to obtain an accurate diagnosis and investigate a possible deficiency.
A vitamin B5 deficiency is rare because pantothenic acid is found in many animal and plant foods. However, some factors increase the risk of inadequate supply. Excessive alcohol consumption can inhibit the absorption of pantothenic acid in the intestine and, through impaired nutrient utilisation, contribute to a deficiency. People with chronic liver disease are also at risk, as vitamin B5 is involved in liver metabolism and insufficient intake can disrupt important processes.
Chronic inflammatory bowel diseases such as Crohn’s disease also hinder absorption of pantothenic acid because the mucous membranes of the digestive tract may be damaged. An unbalanced diet or malnutrition due to eating disorders or a very monotonous diet can also lead to inadequate supply. Older people are particularly at risk, as nutrient absorption often decreases with age.
In addition, loss of vitamin B5 due to external factors such as heat or sunlight can be significant, since pantothenic acid is sensitive to these factors. Because the body stores little of the vitamin, continuous intake is necessary. A deficiency in vitamin B5 often occurs together with a deficiency in other B vitamins, which can complicate diagnosis. A deficiency can only be reliably confirmed by a medical blood test.
Pantothenic acid is a water-soluble vitamin that the body can usually regulate well. An excess normally does not occur because surplus amounts are easily excreted in the urine.
A true overdose is only possible if very high doses, for example 10 grams per day, are taken in the form of vitamin supplements. In that case, mild gastrointestinal complaints such as diarrhoea and abdominal pain may occur.
Serious side effects are not known, however, since pantothenic acid is considered non-toxic. The recommended daily maximum dose is 1'000 milligrams, which is unproblematic for most people.
The daily requirement for pantothenic acid (vitamin B5) varies depending on age, sex and special life circumstances. For adults of both sexes the recommended value is about 5 milligrams per day. Children aged 1 to 10 years require 4 to 5 milligrams per day depending on age. Infants have a lower requirement, between 2 and 3 milligrams per day depending on age.
Breastfeeding women have a slightly increased requirement of 7 milligrams per day, while the requirement during pregnancy is not increased and corresponds to that of non-pregnant women. There are, however, factors that can increase individual needs, for example in people with alcoholism who may have an increased vitamin requirement due to impaired nutrient absorption.
The maximum safe daily dose of pantothenic acid is 200 milligrams, well above the recommended daily dose. This upper limit is set to ensure that no side effects occur.
Pantothenic acid is an essential vitamin involved in numerous metabolic processes and contributes to maintaining health. A varied diet generally ensures adequate supply.


